Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection (Sepsis-3 definition). Between 27 and 30 million septic patients are recorded annually and between 6 to 9 million of these patients die (mortality rate ~ 30%). The cost of treating sepsis is enormous: in 2008 USD 14.6 billion was spent in the US alone (with an average growth rate in cost of 11.9%). Most types of microorganisms can cause sepsis. However, the vast majority of cases is caused by bacteria and fungi.
Experts strongly recommend focusing on the early identification of the sepsis-causing microorganisms to personalize and limit antimicrobial treatment to reduce life-threatening complications. If a patient receives appropriate antimicrobial therapy within the first hour of clinical diagnosis, chances of survival are close to 80%; this goes down by 7.6% for every hour of delay.
Cube Dx' early Pathogen Identification directly from whole blood and other sample matrices reduces time to result to 3 hours. Therefore targeted therapy can be chosen very quickly - even for patients already treated with antimicrobial agents.
The 13th of September marks World Sepsis Day. World Sepsis Day should help to raise awareness of the most deadliest infectious disease of our times. The progression of sepsis - or blood poisoning - is very quick. A person's condition can become life threatening in just a few hours. The incidence of sepsis is on the rise and is driven by an aging population, advances in medicine and the antibiotic crisis.
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The development of Cube Dx' products has been supported under the H2020 funding scheme.