Highly sensitive identification

of bacterial and fungal DNA and resistance genes

Cube Dx molecular pathogen tests support microbiologists and infectious disease specialist in providing early indications of sepsis-causing pathogens in whole blood. As no microbiological culturing is necessary, time to result reduces tremendously.


This is particularly relevant for microorganisms that have been weakened by antimicrobial treatment or which demonstrate slow growth in or on microbiological nutrient media. The broad spectrum of the Cube Dx tests is ideally suited to test for pathogens causing sepsis and other severe infections. 


For such kind of testing a high number of negative results is expected. Therefore it must be ensured that negative results are due to negative samples and not caused by flaws in the process. Therefore we offer a stringent process control that undergoes the same procedures as the sample itself – including pathogen enrichment and DNA extraction.


Cube Dx' Internal Process Control (IPC) consists of frozen bacterial material that is dissolved within the sample. Both qPCR (during the amplification process) and probes on the hybcell (during the identification process) finally confirm the presence of the IPC.


56 species +

11 genera


19 species +

5 genera

Results for mixed infections

9 antibiotic resistance genes

Versatile - for different sample types

Confirmation of negative results


PCR-Boxes: Bacteria (16S) / Fungi (28S) / Resistance

Detection of bacterial 16S / fungal 28S DNA and resistance genes based on (q)PCR

hybcell Bacteria / Fungi / Pathogens DNA

Multiplex DNA tests to identify bacterial fungal and resistance DNA sequences


A frozen solution of microbial cells (put into the sample) and PCR master mix to detect these microbes to serve as internal control

Available literaturE

2016: Sensitive Molecular Identification of Pathogens causing Implant and Tissue Infections (ITI) 

2020: Molecular Pathogen Identification and Resistance Gene Detection from Positive Blood Cultures

2020: Presence and Distribution of Fungal Species and Dermatophytes in Nail and Skin Samples 

2021: SMARTDIAGNOS - Next Generation Molecular Sepsis Diagnosis Technology for Whole Blood Samples

2022: Extraction-free Molecular Identification of Bacteria/Fungi Directly from BAL Samples