Technology / hybcell
The hybcell is the world's first cylindrical microarray, where DNA oligos are immobilized on a cylindrical coated surface. Matching DNA fragments in the sample bind to these probes on the surface. A fluorescence readout shows these interactions.
The hybcell - and therefore the array itself - is constantly moved (rotated) through the sample. This means that the sample is rapidly and homogeneously agitated around the probes coated on the surface, resulting in improved reproducibility, drastic reduction in reaction times, and flexible assay formats (e.g. a sequence of scans and heating and/or cooling steps).
After common hybridization of DNA probes takes place on the microarray’s surface, compact sequencing continues with an enzymatic reaction on the spots (solid phase primer extension), followed by a stringent washing step. The intention of compact sequencing is the differentiation of target DNA down to a single base.
Technology / hyborg
The hyborg processes hybcell assays in a fully automated format. It is tailored for operation in a (clinical) routine laboratory and guarantees limited hands-on time, ease of usage, and clear reports.
The hyborg control and analysis software is a simple-to-use yet powerful tool to organize device runs, operate the hyborg, analyze, and archive results. All reports generated by the software deliver results without the need for interpretation of raw data. Therefore, the time to result is minimal, the outcome does not depend on individuals and processes, and the results are electronically documented.
An outstanding ability of the software is to be able to follow and present trends of results over time for a individual patient.