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Publications & Studies

Independent clinical evaluations of hybcell technology and our products - conducted at various hospitals and medical universities and presented at (microbiology) conferences.

33rd ECCMID, Copenhagen · 2023

Comparison of two molecular assays and MALDI-TOF MS Sepsityper for the rapid identification of pathogens from positive blood cultures

P. Starzengruber, N. Ankowitsch, B. Selitsch, B. Willinger, A. Makristathis

Independent evaluation on 410 positive blood cultures: hybcell Pathogens DNA reached a 94.9 % identification rate on-panel and detected all pathogens in 45.5 % of polymicrobial infections — versus 6.8 % for MALDI-TOF Sepsityper — plus resistance markers only detectable by PCR.

Division of Clinical Microbiology, Medical University of Vienna

33rd ECCMID, Copenhagen · 2023

Diagnostic value of blood-culture-independent molecular tests for the diagnosis of bloodstream infections in neutropenic patients with fever

P. Starzengruber, I. Camp, M. Kussmann, F. Ratzinger, W. R. Sperr, K. Gleixner, B. Selitsch, H. Burgmann, B. Willinger, A. Makristathis

Prospective study in febrile neutropenic patients directly from whole blood: of three commercial molecular tests, only hybcell Pathogens DNA showed acceptable performance (best overall ROC-AUC 0.77), with results available in as little as three hours.

Medical University of Vienna

33rd ECCMID, Copenhagen · 2023

Detection of bacterial pneumonia pathogens in patients with COVID-19 using a commercial microarray in comparison with a commercial multiplex PCR and culture

H. L. Verhasselt, M. I. Sanders, F. Herbstreit, S. Dubler, D. Schmidt, J. Buer, P.-M. Rath

100 respiratory samples (mostly BAL) from ICU COVID-19 patients: the hyborg RED2 / hybcell assay detected Haemophilus influenzae best of all methods (20 vs 3 vs 0) with a 2-hour time-to-result and minimal hands-on time.

Institute of Medical Microbiology, University Hospital Essen (University of Duisburg-Essen)

Evidence

Molecular Microbiology — literature

The technology has been evaluated in independent studies. A selection of available literature:

  1. 2016Sensitive Molecular Identification of Pathogens causing Implant and Tissue Infections (ITI)
  2. 2020Molecular pathogen identification and resistance gene detection from positive blood cultures
  3. 2020Presence and distribution of fungal species and dermatophytes in nail and skin samples
  4. 2021SMARTDIAGNOS – next generation molecular sepsis diagnosis technology for whole blood samples
  5. 2022Extraction-free Molecular Identification of Bacteria/Fungi Directly from BAL Samples
  6. 2023Comparison of two molecular assays and MALDI-TOF MS Sepsityper for the rapid identification of pathogens from positive blood cultures
  7. 2023Detection of bacterial pneumonia pathogens in patients with COVID-19
  8. 2023Diagnostic value of blood culture independent molecular tests for the diagnosis of bloodstream infections in neutropenic patients with fever
  9. 2026Performance comparison to in-house PCR and 16S sequencing
  10. 2026Infective endocarditis: an alternative molecular diagnostic approach to improve laboratory analysis of heart valve tissue
  11. 2026Rapid molecular detection directly from whole blood for the early diagnosis of paediatric bloodstream infections using the cube dx system
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Questions about publications or our applications?

We are happy to share more background information on the publications, our expertise in molecular diagnostics of severe infections, and additional product details with you.

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Sebastian Pürmayr, cube dx team